Need+to+Know

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A. Drug classification based on chemical structure and MOA

B. Major structural features in determing drug potency and pharmaceutical properties

C. MOA of representative drugs

D. History of drug development a. Adrenergic blockers b. HMG-CoA reductase inhibitors c. Cholesterol absorption inhibitors-Ezetimibe d. Direct thrombin inhibitors

E. Drug names that may be tested in the exam Digitoxin Digoxin Lanatoside Amyl nitrite Glyceroltrinitrate Isosorbide dinitrate Erythrityl tetranitrate Pentaerythritol tetranitrate Quinidine Lidocaine Flecainide Propranolol Bretylium tasylate Aminodarone Nifedioine Isradipine PN202.791 Isoprenaline Penbutolol Acebutolol Atenolol Labetalol Prazosin Methyldopa Clonidine Methyrosine Reserpine Hydralazine Sodium nitroprusside Sildenafil Minoxidil Diazoxide Mevastatin Lovastatin Ezetimibe Squalestatin Nicotine acid Gemfibrazil Coumarin Vitamin K Warfarin Brodifacoum 1,3-indandione Heparin Fondarinux Idraparinux Hirudin Bivlirudin